The African Journal of Medicine and Medical Sciences (AJMMS) unit came into existence in 1970 with its first publication in 1971 majorly to provide a medium for wide dissemination of information resulting from biomedical research in Africa and elsewhere. The founding editor was Professor A. Olufemi Williams while the Journal is jointly owned and published by the College of Medicine, University of Ibadan, and University College Hospital, Ibadan, Nigeria. It is a regular quarterly journal, publishing expertly reviewed articles in medicine and medical sciences, particularly those related to medical and health problems in Africa.  The Journal receives articles on original research, review articles and case reports for publication from all parts of Nigeria, Africa, Asia, Europe and the Americas.

At inception, the Journal was published by Blackwell Scientific Publications, Oxford, England. This arrangement was discontinued after June 1991 and the College of Medicine, University of Ibadan and the University College Hospital, Ibadan, Nigeria, publish the Journal now. The Journal is undoubtedly regarded as the best journal emanating from Africa. The Journal remains a quarterly Journal but publishes supplementary issues. The list of such supplements includes theme issue on Malaria, Bioethics, HIV/AIDS, Cancer in Africa and Biotechnology for Health and Development.